| 2010-11 | OHL | Sault Ste. Marie Greyhounds | 66 | 3 | 19 | 22 | 44 | 2 | -- | -- | -- | -- | -- | -- |
| 2011-12 | OHL | Sault Ste. Marie Greyhounds | 54 | 8 | 20 | 28 | 79 | 9 | -- | -- | -- | -- | -- | -- |
| 2012-13 | OHL | Sault Ste. Marie Greyhounds | 54 | 20 | 35 | 55 | 78 | 13 | 6 | 1 | 6 | 7 | 0 | -1 |
| 2013-14 | AHL | Manchester | 65 | 5 | 12 | 17 | 35 | 5 | 3 | 0 | 0 | 0 | 6 | -2 |
| 2014-15 | AHL | Manchester | 70 | 19 | 33 | 52 | 82 | 11 | 19 | 2 | 8 | 10 | 12 | 12 |
| 2015-16 | AHL | Providence Bruins | 20 | 4 | 8 | 12 | 16 | 3 | 2 | 0 | 0 | 0 | 0 | 0 |
| 2015-16 | NHL | Boston Bruins | 42 | 3 | 13 | 16 | 39 | 0 | -- | -- | -- | -- | -- | -- |
| 2016-17 | NHL | Boston Bruins | 61 | 6 | 7 | 13 | 55 | 0 | 4 | 0 | 1 | 1 | 2 | 1 |
| 2017-18 | NHL | Vegas Golden Knights | 82 | 10 | 31 | 41 | 53 | -4 | 20 | 3 | 4 | 7 | 14 | 5 |
| 2018-19 | NHL | Vegas Golden Knights | 65 | 3 | 26 | 29 | 44 | 0 | 6 | 1 | 2 | 3 | 6 | 1 |
| 2019-20 | NHL | Buffalo Sabres | 51 | 1 | 10 | 11 | 22 | -9 | -- | -- | -- | -- | -- | -- |
| 2020-21 | NHL | Buffalo Sabres | 48 | 4 | 8 | 12 | 27 | -20 | -- | -- | -- | -- | -- | -- |
| 2021-22 | NHL | Buffalo Sabres | 38 | 2 | 12 | 14 | 21 | -2 | -- | -- | -- | -- | -- | -- |
| 2022-23 | NHL | Dallas Stars | 79 | 6 | 15 | 21 | 37 | 23 | 10 | 0 | 1 | 1 | 4 | -2 |
| 2023-24 | NHL | New Jersey Devils | 41 | 4 | 4 | 8 | 24 | 10 | -- | -- | -- | -- | -- | -- |
| 2023-24 | NHL | Winnipeg Jets | 5 | 0 | 1 | 1 | 2 | -2 | 1 | 0 | 1 | 1 | 0 | 1 |
| 2024-25 | NHL | Winnipeg Jets | 60 | 4 | 11 | 15 | 38 | 10 | 4 | 0 | 2 | 2 | 4 | 1 |
| 2025-26 | NHL | Winnipeg Jets | 15 | 0 | 1 | 1 | 6 | -8 | -- | -- | -- | -- | -- | -- |
| NHL TOTALS | 587 | 43 | 139 | 182 | 368 | -2 | 45 | 4 | 11 | 15 | 30 | 7 |