

| Regular Season | Playoffs | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Season | League | Team | GP | G | A | Pts | PIM | +/- | GP | G | A | Pts | PIM | +/- |
| 2009-10 | USHL | USNTDP | 35 | 0 | 5 | 5 | 34 | -10 | -- | -- | -- | -- | -- | -- |
| 2010-11 | USHL | USNTDP | 19 | 2 | 4 | 6 | 4 | 6 | -- | -- | -- | -- | -- | -- |
| 2011-12 | WCHA | U. of Wisconsin | 26 | 3 | 9 | 12 | 12 | 0 | -- | -- | -- | -- | -- | -- |
| 2012-13 | WCHA | U. of Wisconsin | 38 | 3 | 18 | 21 | 50 | 0 | -- | -- | -- | -- | -- | -- |
| 2013-14 | Big Ten | U. of Wisconsin | 36 | 8 | 17 | 25 | 53 | 0 | -- | -- | -- | -- | -- | -- |
| 2013-14 | NHL | Buffalo Sabres | 7 | 0 | 1 | 1 | 15 | -3 | -- | -- | -- | -- | -- | -- |
| 2014-15 | AHL | Rochester Americans | 57 | 5 | 24 | 29 | 50 | -3 | -- | -- | -- | -- | -- | -- |
| 2014-15 | NHL | Buffalo Sabres | 2 | 0 | 0 | 0 | 0 | 0 | -- | -- | -- | -- | -- | -- |
| 2015-16 | AHL | Rochester Americans | 1 | 0 | 0 | 0 | 0 | 0 | -- | -- | -- | -- | -- | -- |
| 2015-16 | NHL | Buffalo Sabres | 77 | 4 | 10 | 14 | 51 | 6 | -- | -- | -- | -- | -- | -- |
| 2016-17 | NHL | Buffalo Sabres | 76 | 3 | 17 | 20 | 26 | -7 | -- | -- | -- | -- | -- | -- |
| 2017-18 | NHL | Buffalo Sabres | 53 | 3 | 9 | 12 | 26 | -11 | -- | -- | -- | -- | -- | -- |
| 2018-19 | NHL | Buffalo Sabres | 59 | 4 | 10 | 14 | 35 | -4 | -- | -- | -- | -- | -- | -- |
| 2019-20 | NHL | Buffalo Sabres | 66 | 3 | 10 | 13 | 41 | -11 | -- | -- | -- | -- | -- | -- |
| 2020-21 | NHL | Buffalo Sabres | 13 | 1 | 2 | 3 | 9 | 2 | -- | -- | -- | -- | -- | -- |
| 2021-22 | NHL | Chicago Blackhawks | 75 | 4 | 18 | 22 | 33 | -27 | -- | -- | -- | -- | -- | -- |
| 2022-23 | NHL | Chicago Blackhawks | 55 | 2 | 18 | 20 | 27 | 7 | -- | -- | -- | -- | -- | -- |
| 2022-23 | NHL | Toronto Maple Leafs | 21 | 1 | 4 | 5 | 29 | 12 | 11 | 0 | 2 | 2 | 10 | -7 |
| 2023-24 | NHL | Toronto Maple Leafs | 73 | 8 | 20 | 28 | 56 | 20 | 7 | 1 | 0 | 1 | 4 | 0 |
| 2024-25 | NHL | Toronto Maple Leafs | 66 | 2 | 21 | 23 | 40 | 23 | 13 | 0 | 4 | 4 | 2 | -1 |
| 2025-26 | NHL | Toronto Maple Leafs | 65 | 3 | 17 | 20 | 42 | 8 | -- | -- | -- | -- | -- | -- |
| NHL TOTALS | 708 | 38 | 157 | 195 | 430 | 15 | 31 | 1 | 6 | 7 | 16 | -8 | ||
| Year | Tournament | Team | GP | G | A | Pts | PIM | +/- |
|---|---|---|---|---|---|---|---|---|
| 2013 | World Junior U-20 Championships | Team USA | 7 | 3 | 3 | 6 | 16 | 9 |
| 2014 | IIHF World Championship | Team USA | 7 | 0 | 0 | 0 | 2 | -2 |
| 2016 | IIHF World Championship | Team USA | 8 | 1 | 1 | 2 | 0 | -3 |