| 2001-02 | OHL | Sault Ste. Marie Greyhounds | 63 | 18 | 17 | 35 | 12 | 0 | 4 | 0 | 0 | 0 | 2 | 0 |
| 2002-03 | OHL | Sault Ste. Marie Greyhounds | 61 | 35 | 36 | 71 | 55 | -5 | 4 | 0 | 2 | 2 | 2 | -5 |
| 2003-04 | OHL | Sault Ste. Marie Greyhounds | 57 | 36 | 30 | 66 | 26 | 4 | -- | -- | -- | -- | -- | -- |
| 2003-04 | AHL | Philadelphia | -- | -- | -- | -- | -- | -- | 12 | 4 | 1 | 5 | 0 | -2 |
| 2004-05 | OHL | Sault Ste. Marie Greyhounds | 55 | 34 | 40 | 74 | 40 | 20 | 7 | 5 | 5 | 10 | 6 | 0 |
| 2004-05 | AHL | Philadelphia | 3 | 0 | 1 | 1 | 4 | -1 | 21 | 12 | 11 | 23 | 12 | 10 |
| 2005-06 | NHL | Philadelphia Flyers | 81 | 23 | 19 | 42 | 40 | 10 | 6 | 0 | 0 | 0 | 10 | -4 |
| 2006-07 | NHL | Philadelphia Flyers | 62 | 14 | 23 | 37 | 48 | -17 | -- | -- | -- | -- | -- | -- |
| 2007-08 | NHL | Philadelphia Flyers | 82 | 29 | 24 | 53 | 55 | 6 | 17 | 6 | 5 | 11 | 12 | 0 |
| 2008-09 | NHL | Philadelphia Flyers | 82 | 46 | 38 | 84 | 68 | 23 | 6 | 1 | 0 | 1 | 8 | -2 |
| 2009-10 | NHL | Philadelphia Flyers | 74 | 33 | 28 | 61 | 38 | 2 | 12 | 5 | 2 | 7 | 2 | -5 |
| 2010-11 | NHL | Philadelphia Flyers | 80 | 36 | 30 | 66 | 39 | 27 | 6 | 1 | 1 | 2 | 2 | -3 |
| 2011-12 | NHL | Columbus Blue Jackets | 39 | 15 | 10 | 25 | 14 | -11 | -- | -- | -- | -- | -- | -- |
| 2011-12 | NHL | Los Angeles Kings | 16 | 6 | 3 | 9 | 2 | -1 | 20 | 8 | 5 | 13 | 4 | 0 |
| 2012-13 | NHL | Los Angeles Kings | 48 | 26 | 7 | 33 | 16 | 0 | 18 | 6 | 7 | 13 | 14 | 6 |
| 2013-14 | NHL | Los Angeles Kings | 72 | 27 | 23 | 50 | 44 | 8 | 26 | 10 | 15 | 25 | 4 | 5 |
| 2014-15 | NHL | Los Angeles Kings | 82 | 28 | 34 | 62 | 28 | 7 | -- | -- | -- | -- | -- | -- |
| 2015-16 | NHL | Los Angeles Kings | 77 | 24 | 38 | 62 | 20 | 18 | 5 | 2 | 0 | 2 | 4 | -5 |
| 2016-17 | NHL | Los Angeles Kings | 82 | 32 | 34 | 66 | 41 | 2 | -- | -- | -- | -- | -- | -- |
| 2017-18 | NHL | Los Angeles Kings | 27 | 13 | 9 | 22 | 2 | 4 | 4 | 0 | 0 | 0 | 2 | 0 |
| 2018-19 | NHL | Los Angeles Kings | 76 | 13 | 20 | 33 | 42 | -20 | -- | -- | -- | -- | -- | -- |
| 2019-20 | NHL | Los Angeles Kings | 60 | 17 | 10 | 27 | 36 | -21 | -- | -- | -- | -- | -- | -- |
| 2020-21 | NHL | Los Angeles Kings | 40 | 8 | 11 | 19 | 22 | -6 | -- | -- | -- | -- | -- | -- |
| 2020-21 | NHL | Pittsburgh Penguins | 14 | 9 | 2 | 11 | 0 | 9 | 6 | 4 | 1 | 5 | 4 | 0 |
| 2021-22 | NHL | Pittsburgh Penguins | 76 | 19 | 26 | 45 | 38 | -8 | 7 | 4 | 1 | 5 | 6 | -6 |
| 2022-23 | NHL | Pittsburgh Penguins | 79 | 13 | 16 | 29 | 30 | -16 | -- | -- | -- | -- | -- | -- |
| 2023-24 | NHL | Pittsburgh Penguins | 72 | 11 | 4 | 15 | 12 | -7 | -- | -- | -- | -- | -- | -- |
| NHL TOTALS | 1321 | 442 | 409 | 851 | 635 | 9 | 133 | 47 | 37 | 84 | 72 | -14 |