| 1995-96 | OHL | Sault Ste. Marie Greyhounds | 66 | 30 | 46 | 76 | 53 | 0 | 4 | 1 | 1 | 2 | 11 | 0 |
| 1996-97 | OHL | Sault Ste. Marie Greyhounds | 59 | 41 | 81 | 122 | 123 | 0 | 11 | 11 | 8 | 19 | 24 | 0 |
| 1997-98 | NHL | Boston Bruins | 55 | 3 | 4 | 7 | 19 | -6 | 6 | 0 | 0 | 0 | 9 | 0 |
| 1998-99 | NHL | Boston Bruins | 81 | 16 | 25 | 41 | 69 | 3 | 11 | 3 | 6 | 9 | 4 | 1 |
| 1999-00 | NHL | Boston Bruins | 81 | 23 | 37 | 60 | 82 | -5 | -- | -- | -- | -- | -- | -- |
| 2000-01 | NHL | Boston Bruins | 72 | 37 | 34 | 71 | 107 | -4 | -- | -- | -- | -- | -- | -- |
| 2001-02 | NHL | Boston Bruins | 66 | 22 | 46 | 68 | 127 | 7 | 6 | 2 | 4 | 6 | 10 | 0 |
| 2002-03 | NHL | Boston Bruins | 77 | 36 | 65 | 101 | 109 | 12 | 5 | 1 | 2 | 3 | 4 | -5 |
| 2003-04 | NHL | Boston Bruins | 77 | 23 | 50 | 73 | 98 | 18 | 7 | 0 | 0 | 0 | 14 | -6 |
| 2005-06 | NHL | Boston Bruins | 23 | 9 | 24 | 33 | 6 | 0 | -- | -- | -- | -- | -- | -- |
| 2005-06 | NHL | San Jose Sharks | 58 | 20 | 72 | 92 | 55 | 31 | 11 | 2 | 7 | 9 | 12 | -4 |
| 2006-07 | NHL | San Jose Sharks | 82 | 22 | 92 | 114 | 44 | 24 | 11 | 1 | 10 | 11 | 10 | 2 |
| 2007-08 | NHL | San Jose Sharks | 82 | 29 | 67 | 96 | 59 | 18 | 13 | 2 | 8 | 10 | 2 | 3 |
| 2008-09 | NHL | San Jose Sharks | 82 | 25 | 61 | 86 | 56 | 16 | 6 | 1 | 4 | 5 | 5 | -3 |
| 2009-10 | NHL | San Jose Sharks | 79 | 20 | 69 | 89 | 54 | 17 | 15 | 3 | 9 | 12 | 18 | -11 |
| 2010-11 | NHL | San Jose Sharks | 80 | 21 | 49 | 70 | 47 | 4 | 18 | 3 | 14 | 17 | 16 | -5 |
| 2011-12 | NHL | San Jose Sharks | 82 | 18 | 59 | 77 | 31 | 17 | 5 | 2 | 3 | 5 | 2 | 2 |
| 2012-13 | NHL | San Jose Sharks | 48 | 7 | 33 | 40 | 26 | 6 | 11 | 2 | 8 | 10 | 2 | 5 |
| 2013-14 | NHL | San Jose Sharks | 82 | 11 | 65 | 76 | 32 | 20 | 7 | 2 | 1 | 3 | 8 | -6 |
| 2014-15 | NHL | San Jose Sharks | 78 | 16 | 49 | 65 | 30 | -4 | -- | -- | -- | -- | -- | -- |
| 2015-16 | NHL | San Jose Sharks | 82 | 19 | 63 | 82 | 54 | 25 | 24 | 3 | 18 | 21 | 10 | 2 |
| 2016-17 | NHL | San Jose Sharks | 79 | 7 | 43 | 50 | 51 | 7 | 4 | 0 | 2 | 2 | 0 | -1 |
| 2017-18 | NHL | San Jose Sharks | 47 | 13 | 23 | 36 | 38 | -9 | -- | -- | -- | -- | -- | -- |
| 2018-19 | NHL | San Jose Sharks | 73 | 16 | 35 | 51 | 20 | 8 | 19 | 4 | 6 | 10 | 6 | -6 |
| 2019-20 | NHL | San Jose Sharks | 70 | 7 | 24 | 31 | 34 | -19 | -- | -- | -- | -- | -- | -- |
| 2020-21 | NHL | Toronto Maple Leafs | 44 | 5 | 15 | 20 | 14 | 6 | 7 | 1 | 0 | 1 | 2 | -3 |
| 2021-22 | NHL | Florida Panthers | 34 | 5 | 5 | 10 | 10 | -10 | 1 | 0 | 0 | 0 | 0 | -1 |
| NHL TOTALS | 1714 | 430 | 1109 | 1539 | 1272 | 182 | 187 | 32 | 102 | 134 | 134 | -36 |