| 2014-15 | AHL | Wilkes-Barre/Scranton Penguins | 4 | 1 | 1 | 2 | 0 | -1 | 7 | 3 | 2 | 5 | 0 | 0 |
| 2015-16 | AHL | Toronto Marlies | 44 | 9 | 16 | 25 | 8 | 7 | 14 | 3 | 5 | 8 | 2 | 1 |
| 2015-16 | NHL | Toronto Maple Leafs | 9 | 0 | 0 | 0 | 2 | -3 | -- | -- | -- | -- | -- | -- |
| 2016-17 | AHL | Toronto Marlies | 43 | 18 | 25 | 43 | 16 | 2 | 9 | 2 | 6 | 8 | 8 | -2 |
| 2016-17 | NHL | Toronto Maple Leafs | 8 | 1 | 0 | 1 | 0 | -2 | 6 | 2 | 0 | 2 | 0 | -2 |
| 2017-18 | AHL | Toronto Marlies | 28 | 12 | 12 | 24 | 12 | 8 | -- | -- | -- | -- | -- | -- |
| 2017-18 | NHL | Toronto Maple Leafs | 38 | 7 | 2 | 9 | 4 | -1 | 7 | 1 | 0 | 1 | 0 | -3 |
| 2018-19 | NHL | Toronto Maple Leafs | 78 | 20 | 24 | 44 | 27 | 12 | 7 | 1 | 1 | 2 | 2 | -1 |
| 2019-20 | NHL | Toronto Maple Leafs | 69 | 13 | 23 | 36 | 22 | 0 | 5 | 0 | 2 | 2 | 14 | -2 |
| 2020-21 | NHL | Pittsburgh Penguins | 40 | 11 | 19 | 30 | 7 | 15 | 6 | 1 | 2 | 3 | 0 | -3 |
| 2021-22 | NHL | Pittsburgh Penguins | 79 | 11 | 21 | 32 | 16 | 2 | 7 | 0 | 3 | 3 | 2 | 4 |
| 2022-23 | NHL | Pittsburgh Penguins | 43 | 7 | 13 | 20 | 8 | -8 | -- | -- | -- | -- | -- | -- |
| 2022-23 | NHL | St. Louis Blues | 23 | 8 | 6 | 14 | 10 | 0 | -- | -- | -- | -- | -- | -- |
| 2023-24 | NHL | St. Louis Blues | 73 | 6 | 16 | 22 | 14 | -5 | -- | -- | -- | -- | -- | -- |
| 2024-25 | NHL | St. Louis Blues | 10 | 1 | 0 | 1 | 2 | -6 | -- | -- | -- | -- | -- | -- |
| 2024-25 | NHL | Edmonton Oilers | 57 | 5 | 8 | 13 | 14 | -16 | 12 | 3 | 3 | 6 | 18 | 4 |
| 2025-26 | NHL | Edmonton Oilers | 26 | 7 | 8 | 15 | 6 | 7 | -- | -- | -- | -- | -- | -- |
| NHL TOTALS | 553 | 97 | 140 | 237 | 132 | -5 | 50 | 8 | 11 | 19 | 36 | -3 |