| 2004-05 | QMJHL | Val-d'Or Foreurs | 70 | 13 | 19 | 32 | 79 | -16 | -- | -- | -- | -- | -- | -- |
| 2005-06 | QMJHL | Val-d'Or Foreurs | 60 | 25 | 43 | 68 | 156 | 4 | 5 | 1 | 5 | 6 | 20 | -5 |
| 2006-07 | QMJHL | Val-d'Or Foreurs | 40 | 14 | 38 | 52 | 74 | 19 | 19 | 12 | 19 | 31 | 48 | 10 |
| 2006-07 | AHL | Wilkes-Barre/Scranton Penguins | -- | -- | -- | -- | -- | -- | 1 | 0 | 1 | 1 | 2 | 0 |
| 2006-07 | NHL | Pittsburgh Penguins | 7 | 2 | 0 | 2 | 4 | -3 | -- | -- | -- | -- | -- | -- |
| 2007-08 | AHL | Wilkes-Barre/Scranton Penguins | 10 | 1 | 6 | 7 | 4 | 0 | -- | -- | -- | -- | -- | -- |
| 2007-08 | NHL | Pittsburgh Penguins | 63 | 6 | 11 | 17 | 23 | -1 | 16 | 0 | 2 | 2 | 12 | 5 |
| 2008-09 | NHL | Pittsburgh Penguins | 74 | 10 | 23 | 33 | 24 | -7 | 23 | 4 | 9 | 13 | 26 | 1 |
| 2009-10 | NHL | Pittsburgh Penguins | 73 | 3 | 24 | 27 | 51 | 1 | 13 | 5 | 2 | 7 | 6 | -5 |
| 2010-11 | NHL | Pittsburgh Penguins | 82 | 8 | 42 | 50 | 101 | 15 | 7 | 0 | 4 | 4 | 10 | 0 |
| 2011-12 | NHL | Pittsburgh Penguins | 51 | 10 | 32 | 42 | 34 | 21 | 6 | 1 | 4 | 5 | 21 | -1 |
| 2012-13 | NHL | Pittsburgh Penguins | 35 | 5 | 33 | 38 | 8 | 16 | 15 | 3 | 13 | 16 | 8 | 2 |
| 2013-14 | NHL | Pittsburgh Penguins | 37 | 11 | 11 | 22 | 16 | -8 | 13 | 2 | 4 | 6 | 14 | 2 |
| 2014-15 | NHL | Pittsburgh Penguins | 69 | 11 | 43 | 54 | 79 | 12 | -- | -- | -- | -- | -- | -- |
| 2015-16 | NHL | Pittsburgh Penguins | 71 | 16 | 51 | 67 | 66 | 9 | 23 | 3 | 12 | 15 | 22 | 6 |
| 2016-17 | NHL | Pittsburgh Penguins | 41 | 5 | 29 | 34 | 32 | 2 | -- | -- | -- | -- | -- | -- |
| 2017-18 | NHL | Pittsburgh Penguins | 79 | 9 | 42 | 51 | 56 | -9 | 12 | 3 | 8 | 11 | 15 | 0 |
| 2018-19 | NHL | Pittsburgh Penguins | 65 | 16 | 40 | 56 | 48 | 13 | 4 | 0 | 1 | 1 | 2 | -3 |
| 2019-20 | NHL | Pittsburgh Penguins | 61 | 15 | 29 | 44 | 38 | 0 | 4 | 0 | 0 | 0 | 0 | -2 |
| 2020-21 | NHL | Pittsburgh Penguins | 55 | 7 | 38 | 45 | 32 | 19 | 6 | 1 | 5 | 6 | 6 | -2 |
| 2021-22 | NHL | Pittsburgh Penguins | 78 | 10 | 58 | 68 | 49 | 20 | 7 | 1 | 3 | 4 | 0 | -3 |
| 2022-23 | NHL | Pittsburgh Penguins | 64 | 12 | 29 | 41 | 30 | -13 | -- | -- | -- | -- | -- | -- |
| 2023-24 | NHL | Pittsburgh Penguins | 82 | 10 | 41 | 51 | 62 | 13 | -- | -- | -- | -- | -- | -- |
| 2024-25 | NHL | Pittsburgh Penguins | 74 | 9 | 21 | 30 | 52 | -15 | -- | -- | -- | -- | -- | -- |
| 2025-26 | NHL | Pittsburgh Penguins | 60 | 3 | 24 | 27 | 34 | -5 | -- | -- | -- | -- | -- | -- |
| NHL TOTALS | 1221 | 178 | 621 | 799 | 839 | 80 | 149 | 23 | 67 | 90 | 142 | 0 |