| 2000-01 | QMJHL | Cape Breton Eagles | 35 | 12 | 13 | 2 | 0 | 0 | 4.05 | -- | 2 | 0 | 1 | 0 | 0 | 0 | 7.50 | -- |
| 2001-02 | QMJHL | Cape Breton Eagles | 55 | 26 | 14 | 8 | 2 | 0 | 2.78 | -- | 16 | 9 | 7 | 0 | 0 | 0 | 3.29 | -- |
| 2002-03 | QMJHL | Cape Breton Eagles | 51 | 17 | 24 | 6 | 2 | 1800 | 3.36 | 0.910 | 4 | 0 | 4 | 0 | 0 | 178 | 4.47 | 0.904 |
| 2003-04 | QMJHL | Cape Breton Eagles | 10 | 8 | 1 | 1 | 0 | 297 | 1.98 | 0.933 | 4 | 1 | 3 | 0 | 0 | 114 | 3.10 | 0.886 |
| 2003-04 | AHL | Wilkes-Barre/Scranton Penguins | -- | -- | -- | -- | -- | -- | -- | -- | 2 | 0 | 1 | 0 | 0 | 30 | 3.90 | 0.800 |
| 2003-04 | NHL | Pittsburgh Penguins | 21 | 4 | 14 | 2 | 1 | 675 | 3.64 | 0.896 | -- | -- | -- | -- | -- | -- | -- | -- |
| 2004-05 | AHL | Wilkes-Barre/Scranton Penguins | 54 | 26 | 19 | 4 | 5 | 1286 | 2.52 | 0.901 | 4 | 0 | 2 | 0 | 0 | 70 | 4.36 | 0.843 |
| 2005-06 | AHL | Wilkes-Barre/Scranton Penguins | 12 | 10 | 2 | 0 | 0 | 312 | 1.57 | 0.939 | 5 | 2 | 3 | 0 | 0 | 154 | 3.48 | 0.883 |
| 2005-06 | NHL | Pittsburgh Penguins | 50 | 13 | 27 | 6 | 1 | 1485 | 3.25 | 0.898 | -- | -- | -- | -- | -- | -- | -- | -- |
| 2006-07 | NHL | Pittsburgh Penguins | 67 | 40 | 16 | 9 | 5 | 1954 | 2.83 | 0.906 | 5 | 1 | 4 | 0 | 0 | 150 | 3.77 | 0.880 |
| 2007-08 | AHL | Wilkes-Barre/Scranton Penguins | 5 | 3 | 2 | 0 | 0 | 140 | 1.42 | 0.950 | -- | -- | -- | -- | -- | -- | -- | -- |
| 2007-08 | NHL | Pittsburgh Penguins | 35 | 19 | 10 | 2 | 4 | 909 | 2.33 | 0.921 | 20 | 14 | 6 | 0 | 3 | 610 | 1.97 | 0.933 |
| 2008-09 | NHL | Pittsburgh Penguins | 62 | 35 | 18 | 7 | 4 | 1850 | 2.67 | 0.912 | 24 | 16 | 8 | 0 | 0 | 686 | 2.61 | 0.908 |
| 2009-10 | NHL | Pittsburgh Penguins | 67 | 37 | 21 | 6 | 1 | 1772 | 2.65 | 0.905 | 13 | 7 | 6 | 0 | 1 | 339 | 2.78 | 0.891 |
| 2010-11 | NHL | Pittsburgh Penguins | 65 | 36 | 20 | 5 | 3 | 1742 | 2.32 | 0.918 | 7 | 3 | 4 | 0 | 1 | 168 | 2.52 | 0.899 |
| 2011-12 | NHL | Pittsburgh Penguins | 67 | 42 | 17 | 4 | 3 | 1768 | 2.36 | 0.913 | 6 | 2 | 4 | 0 | 0 | 157 | 4.63 | 0.834 |
| 2012-13 | NHL | Pittsburgh Penguins | 33 | 23 | 8 | 0 | 1 | 881 | 2.39 | 0.916 | 5 | 2 | 2 | 0 | 1 | 145 | 3.51 | 0.883 |
| 2013-14 | NHL | Pittsburgh Penguins | 64 | 39 | 18 | 5 | 5 | 1774 | 2.37 | 0.915 | 13 | 7 | 6 | 0 | 2 | 378 | 2.40 | 0.915 |
| 2014-15 | NHL | Pittsburgh Penguins | 64 | 34 | 20 | 9 | 10 | 1831 | 2.32 | 0.920 | 5 | 1 | 4 | 0 | 0 | 150 | 2.12 | 0.927 |
| 2015-16 | NHL | Pittsburgh Penguins | 58 | 35 | 17 | 6 | 5 | 1665 | 2.29 | 0.921 | 2 | 0 | 1 | 0 | 0 | 32 | 3.03 | 0.875 |
| 2016-17 | NHL | Pittsburgh Penguins | 38 | 18 | 10 | 7 | 1 | 1181 | 3.02 | 0.909 | 15 | 9 | 6 | 0 | 2 | 490 | 2.56 | 0.924 |
| 2017-18 | NHL | Vegas Golden Knights | 46 | 29 | 13 | 4 | 4 | 1376 | 2.24 | 0.927 | 20 | 13 | 7 | 0 | 4 | 641 | 2.24 | 0.927 |
| 2018-19 | NHL | Vegas Golden Knights | 61 | 35 | 21 | 5 | 8 | 1745 | 2.51 | 0.913 | 7 | 3 | 4 | 0 | 1 | 230 | 2.70 | 0.909 |
| 2019-20 | NHL | Vegas Golden Knights | 49 | 27 | 16 | 5 | 5 | 1399 | 2.77 | 0.905 | 4 | 3 | 1 | 0 | 0 | 100 | 2.27 | 0.910 |
| 2020-21 | NHL | Vegas Golden Knights | 36 | 26 | 10 | 0 | 6 | 989 | 1.98 | 0.928 | 16 | 9 | 7 | 0 | 1 | 403 | 2.04 | 0.918 |
| 2021-22 | NHL | Chicago Blackhawks | 45 | 19 | 21 | 5 | 4 | 1398 | 2.95 | 0.908 | -- | -- | -- | -- | -- | -- | -- | -- |
| 2021-22 | NHL | Minnesota Wild | 11 | 9 | 2 | 0 | 0 | 334 | 2.74 | 0.910 | 5 | 2 | 3 | 0 | 0 | 159 | 3.04 | 0.906 |
| 2022-23 | NHL | Minnesota Wild | 46 | 24 | 16 | 4 | 2 | 1367 | 2.85 | 0.908 | 2 | 0 | 1 | 0 | 0 | 37 | 5.48 | 0.811 |
| 2023-24 | NHL | Minnesota Wild | 40 | 17 | 15 | 5 | 2 | 1056 | 2.98 | 0.895 | -- | -- | -- | -- | -- | -- | -- | -- |
| 2024-25 | NHL | Minnesota Wild | 26 | 14 | 9 | 1 | 1 | 670 | 2.93 | 0.899 | 1 | 0 | 1 | 0 | 0 | 7 | 2.49 | 0.857 |
| NHL TOTALS | 1051 | 575 | 339 | 97 | 76 | 29821 | 2.60 | 0.912 | 170 | 92 | 75 | 0 | 16 | 4882 | 2.56 | 0.911 |