| 2009-10 | OHL | Sault Ste. Marie Greyhounds | 47 | 27 | 13 | 3 | 5 | 1457 | 2.80 | 0.918 | 5 | 1 | 4 | 0 | 0 | 159 | 4.30 | 0.874 |
| 2009-10 | AHL | Binghamton | 2 | 2 | 0 | 0 | 0 | 59 | 3.00 | 0.898 | -- | -- | -- | -- | -- | -- | -- | -- |
| 2010-11 | AHL | Binghamton | 22 | 10 | 8 | 2 | 3 | 581 | 2.70 | 0.912 | 19 | 14 | 4 | 0 | 3 | 639 | 2.10 | 0.939 |
| 2010-11 | NHL | Ottawa Senators | 8 | 1 | 4 | 0 | 0 | 178 | 3.52 | 0.888 | -- | -- | -- | -- | -- | -- | -- | -- |
| 2011-12 | AHL | Binghamton | 40 | 13 | 22 | 1 | 2 | 1275 | 3.26 | 0.907 | -- | -- | -- | -- | -- | -- | -- | -- |
| 2011-12 | NHL | Ottawa Senators | 5 | 3 | 2 | 0 | 1 | 154 | 2.01 | 0.935 | -- | -- | -- | -- | -- | -- | -- | -- |
| 2012-13 | AHL | Binghamton | 31 | 18 | 10 | 2 | 3 | 1046 | 2.12 | 0.938 | -- | -- | -- | -- | -- | -- | -- | -- |
| 2012-13 | NHL | Ottawa Senators | 12 | 5 | 3 | 4 | 0 | 424 | 2.20 | 0.936 | 2 | 0 | 1 | 0 | 0 | 25 | 2.43 | 0.920 |
| 2013-14 | NHL | Ottawa Senators | 36 | 12 | 15 | 6 | 1 | 1141 | 3.06 | 0.913 | -- | -- | -- | -- | -- | -- | -- | -- |
| 2014-15 | NHL | Ottawa Senators | 25 | 9 | 12 | 3 | 0 | 779 | 3.02 | 0.905 | -- | -- | -- | -- | -- | -- | -- | -- |
| 2015-16 | AHL | Rochester Americans | 3 | 1 | 2 | 0 | 0 | 89 | 3.36 | 0.888 | -- | -- | -- | -- | -- | -- | -- | -- |
| 2015-16 | NHL | Buffalo Sabres | 21 | 5 | 9 | 5 | 1 | 634 | 2.47 | 0.924 | -- | -- | -- | -- | -- | -- | -- | -- |
| 2016-17 | NHL | Buffalo Sabres | 59 | 23 | 26 | 8 | 2 | 1910 | 2.68 | 0.920 | -- | -- | -- | -- | -- | -- | -- | -- |
| 2017-18 | NHL | Buffalo Sabres | 53 | 14 | 26 | 9 | 3 | 1560 | 3.01 | 0.908 | -- | -- | -- | -- | -- | -- | -- | -- |
| 2018-19 | NHL | New York Islanders | 46 | 25 | 13 | 5 | 6 | 1323 | 2.13 | 0.930 | 8 | 4 | 4 | 0 | 0 | 233 | 2.00 | 0.936 |
| 2019-20 | NHL | Chicago Blackhawks | 33 | 16 | 10 | 5 | 0 | 1152 | 3.01 | 0.918 | -- | -- | -- | -- | -- | -- | -- | -- |
| 2019-20 | NHL | Vegas Golden Knights | 3 | 3 | 0 | 0 | 1 | 83 | 1.67 | 0.940 | 16 | 9 | 7 | 0 | 4 | 386 | 1.99 | 0.917 |
| 2020-21 | NHL | Vegas Golden Knights | 19 | 13 | 4 | 2 | 1 | 505 | 2.29 | 0.913 | 3 | 1 | 2 | 0 | 0 | 97 | 3.62 | 0.887 |
| 2021-22 | NHL | Vegas Golden Knights | 44 | 23 | 17 | 2 | 1 | 1288 | 2.83 | 0.907 | -- | -- | -- | -- | -- | -- | -- | -- |
| NHL TOTALS | 364 | 152 | 141 | 49 | 17 | 11131 | 2.71 | 0.917 | 29 | 14 | 14 | 0 | 4 | 741 | 2.19 | 0.919 |